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Inventi Impact: Medicine

Articles

  • Inventi:hhm/16528/15
    The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract\nSupplementation on Functional Dyspepsia: A Randomised, Double-blind, and Placebo-controlled\nClinical Trial
    01-Jan-1970 Research 2015 : July - September
    Attilio Giacosa, Davide Guido, Mario Grassi, Antonella Riva, Paolo Morazzoni, Ezio Bombardelli, Simone Perna, Milena A Faliva, Mariangela Rondanelli

    Objective. Functional dyspepsia (FD) is a frequent clinical finding in western world.The aim of this study is to compare the efficacy\nof a ginger and artichoke supplementation versus placebo in the treatment of FD. Methods. A prospective multicentre, double\nblind, randomized, placebo controlled, parallel-group comparison of the supplement and placebo over a period of 4 weeks was\nperformed. Two capsules/daywere supplied (before lunch and dinner) to 126 FD patients (supplementation/placebo: 65/61). Results.\nAfter 14 days of treatment, only supplementation group (SG) showed a significant amelioration (SG: ?S = +1.195 MCA score\nunits (u), P = 0.017; placebo: ?P = +0.347 u, P = 0.513). The intercept (?) resulted to be significantly higher in SG than in\nplacebo (?S ? ?P = +0.848 u, P < 0.001). At the end of the study, the advantage of SG versus placebo persists without variation\n(?S ? ?P = +0.077 u, P = 0.542). In SG, a significant advantage is observed for nausea (?S ? ?P = ?0.398 u, P < 0.001), epigastric\nfullness (?S ? ?P = ?0.241, P < 0.001), epigastric pain (?S ? ?P = ?0.173 u, P = 0.002), and bloating (?S ? ?P = ?0.167 u,\nP = 0.017). Conclusions.The association between ginger and artichoke leaf extracts appears safe and efficacious in the treatment of\nFD and could represent a promising treatment for this disease.

    How to Cite this Article
    CC Compliant Citation: Attilio Giacosa, Davide Guido, Mario Grassi, et al., â??The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara\ncardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial,â?\nEvidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 915087, 9 pages, 2015. doi:10.1155/2015/915087, http://\ncreativecommons.org/licenses/by/3.0/.
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